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1) Complications of diabetes mellitus Chronic hyperglycaemia causes irreversible damage over time to a number of tissues: particularly the small blood vessels of the retina (retinopathy), the glomerulus (nephropathy) and peripheral nerves (peripheral neuropathy). These are the microvascular complications. They are strongly linked to long term elevated blood glucose. Macro vascular complications are further divided into coronary circulation ( angina, acute coronary syndrome or myocardial infarction), cerebral circulation (transient ischaemic attack, stroke), peripheral circulation ( foot diseases). other complications are - infections, rheumatological complications, skin complications. 2. Diabetic neuropathy symptoms include paraesthesia in the feet, sharp pain in lower limbs ( worse at night and felt mainly on the anterior aspect of the leg), burning sensation in the soles of feet and cutaneous hyperaesthesia. As the condition advances, structural changes appear ...